a.k.a. Minerocorticoid receptor antagonist, K-sparing diuretics, Aldosterone antagonist

Examples:

• Spironolactone
• Epleronone
• (Non-steroidal): Finerenone

Effect: diuretic (decrease 1-2% Na reabsorption → decrease BV → decrease BP)

• The only Diuretics that increases, instead of decreases, K+ in blood

Conditions

Volume overload

• ↑High BP
• Congestive HF - Heart Failure
• Spironolactone: Acne (androgenic)
• Hyperaldosteronism ↑
• Ascites acute management

CI

• !Hyperkalemia - ↑K (> 5)
• ↓Adrenal Insufficiency (Addison’s) (useless)