Type I Diabetes Mellitus

10% of the diabetes cases

Relevant Physiology

Physiology

Etiology + Pathogenesis

Natural history

Presentation

Signs and Symptoms

• Clinical presentation (HPI):
  • Weight loss
  • Fruity Breath
  • Lethargic (GCS 13–15)
  • Psychogenic Polydipsia
  • Polyuria
  • Blurry Vision
• Complications:
  • No insulin → !DKA - Diabetic KetoAcidosis
  • Diabetes Complications
• Physical Exam Findings

Risk factors

Investigation

Investigation

• Fasting glucose (≤ 7.0)
• HbA1c (< 6.5)
• Can also do Random Glucose (2.5 - 6) and 2hOGTT (< 7.8)

Diagnostic Criteria

2hPG, 2-hour plasma glucose; AlC, glycated hemoglobin; FPG, fasting plasma glucose; OGTT, oral glucose tolerance test; PG, plasma glucose.

2hPG, 2-hour plasma glucose; AlC, glycated hemoglobin; FPG, fasting plasma glucose; OGTT, oral glucose tolerance test; PG, plasma glucose.

Management

Medication

• SC Insulin