Measurement

Ions	Conditions	Impact on ‣ → a.k.a. AV conduction at SA/AV node	Impact on ‣ → a.k.a. time for deploarization/repolarization at Cardiac myocyte
‣	‣	Increase threshold potential (‣)
= ‣
= ‣	More rapid depolarization at ‣
= ‣
	‣		Opposite,
= ‣
‣	‣	Increase RMP = inactivate Na channel = less ‣ current
= ‣
→ loss AV conduction
= ‣
= ‣	More rapid re-polarization at ‣
= ‣

	‣		Opposite,
= ‣

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Ionized Ca (1.05-1.3)

*in MM - Multiple Myeloma, when Ca-binding-Ig is present, uses Ionized Ca (1.05-1.3)

Calcium should be checked with Albumin (40) , as the amount of albumin affect the amount of ionized calcium

Hypoalbuminemia (< 40) (normal = 40)

Solution:

Measure Ionized Ca (1.05-1.3), OR
Correcting rule (”Corrected Ca”)
- For every 10g/L of Albumin decrease, serum calcium falls by 0.02 g/L
<aside> 💡 Corrected Ca = measured Ca + 0.02 * (40 - measured Albumin)

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