<aside> 💡 *In anyone with a uterus, Estrogen treatment must be combined with Progesterone-related drugs to avoid Uterine hyperplasia .

</aside>

Examples:

• 17B - Estradiol (Estrace®) → HRT
• CEE - (Premarin)® → HRT
• EE - Ethinyl estradiol → cOCP (more potent)

Effect:

• Oral contraceptive

• Cardio-protective

• Feminizing

  • Irreversible
  • Reservable

CI:

Side effects & Administration

• Oral (17B - Estradiol (Estrace®) )
  • Increased risk of VTE
  • Increase risk for Gallstone Diseases
• Transdermal
  • Expensive
  • Reserved for:
    • High risk patient (HOMaC)
      • Migraine with Aura
      • ↑High BP
      • Obesity
      • VTE Hx
        • !PE - Pulmonary embolism or DVT
      • Gallstone Diseases Hx

    • 45 yr old in Gender Affirming Care

• Estrogel
• Estradiol Vaginal Cream 0.01%