Relevant Physiology

Etiology

• PIT-NET

GH Physiology

Presentation

• Appearance
• CTS - Carpal Tunnel Syndrome (enlargement of bone → trapping median nerve)
• OA - Osteoarthritis
• Cardiomegaly, CAD
• Hyperhidrosis (Excessive sweating with heat or exercise)
  • VS Perspiration/Diaphoresis
• Colonic polyps
• OSA - Obstructive Sleep Apnea
• Multinodular Goitre, Goitre
• Metabolic syndrome
• Pituitary Tumor Mass Effect

Investigation

• Screening:IGF-1 Level
  • Hormone panel to investigate Anterior Pituitary Diseases
• Suppression Test: OGTT (< 7.8) → Measure GH level
  • Normal: GH suppressed to less than 1 ug/L

Management