Single Pill Combination for ↑High BP

• Preferred approach:
  • Better efficacy
  • Less side effects

1. ACEi(-pril) or ARB (-sartan) + CCB
   • ARB + CCB: Balance pedal edema side-effects
2. ACEi(-pril) or ARB (-sartan) + Thiazide-like Diuretics
   • Balance K side-effects

• ACE-I with CCB (e.g. perindopril-amlodipine) • ARB with CCB (e.g. telmisartan-amlodipine) • ACE-I or ARB, with diuretic (e.g. perindopril-indapamide; candesartan-hydrochlorothiazide)