ARB = Angiotensin Receptor Blocker

Examples:

• Candesartan → also good for Migraine
• Irbesartan
• Valsartan
• Losartan

Effect: decrease BP (vasodilation), decrease BV by decreasing sodium re-absorption in the kidney (no aldosterone)

• Afferent Arteriole (AA) andEfferent Arteriole, Glomerulus
• Angiotensin II (Ang II) receptor subtypes AT1 and AT2 have been identified in the afferent and efferent arterioles, glomeruli, mesangial cells, and proximal tubules.

Conditions:

Less preferred compared to ACEi(-pril) → the 2 should NOT be combined

• HFrEF (HF w/ reduced EF)
• ↑High BP

CI:

• !Hyperkalemia - ↑K (> 5)
  • *aldosterone → K+ retention
• CKD : GFR < 30

MOA: block type 1 Angiotensin II receptor → prevent vasoconstriction & aldosterone production